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1

Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau

Bin Li, Muhammad Omar Chohan, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Acta Neuropathologica

Year:

2007

Language:

english

File:

PDF, 944 KB

english, 2007

2

O2-05-06 Impaired glucose uptake/metabolism contributes to hyperphosphorylation of tau via reduction of O-GLCnacylation: a novel mechanism involved in Alzheimer disease

Cheng-Xin Gong, Fei Liu, Li Xu, Jianzhi Wang, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 168 KB

english, 2004

3

THE WANDERVOGEL SYNDROME

Chohan, Muhammad O., Alonso, Alejandra, Haque, Niloufar, El-Akkad, Ezzat, Grundke-Iqbal, Inge, Grover, Andrew, Iqbal, Khalid

Journal:

Year:

1966

Language:

english

File:

PDF, 328 KB

english, 1966

4

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

Ying Liu, Fei Liu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong

Journal:

The Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 4.04 MB

english, 2011

5

Alzheimer's disease, a multifactorial disorder seeking multitherapies

Khalid Iqbal, Inge Grundke-Iqbal

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 451 KB

english, 2010

6

Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules

Khalid Iqbal, Inge Grundke-Iqbal, Henryk M. Wisniewski, Robert D. Terry

Journal:

Year:

1978

Language:

english

File:

PDF, 3.41 MB

english, 1978

7

EVIDENCE THAT ALZHEIMER NEUROFIBRILLARY TANGLES ORIGINATE FROM NEUROTUBULES

Grundke-Iqbal, Inge, Wisniewski, HenrykM, Johnson, AnneB, Terry, RobertD, Iqbal, Khalid

Journal:

Year:

1979

Language:

english

File:

PDF, 546 KB

english, 1979

8

Alzheimer disease hyperphosphorylated tau aggregates hydrophobically

George C. Ruben, Thomas L. Ciardelli, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Year:

1997

Language:

english

File:

PDF, 1.95 MB

english, 1997

9

Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers

Khalid Iqbal, Michael Flory, Sabiha Khatoon, Hilkka Soininen, Tuula Pirttila, Maarit Lehtovirta, Irina Alafuzoff, Kaj Blennow, Niels Andreasen, Eugeen Vanmechelen, Inge Grundke-Iqbal

Journal:

Annals of Neurology

Year:

2005

Language:

english

File:

PDF, 516 KB

english, 2005

10

Alzheimer neurofibrillary tangles: Antiserum and immunohistological staining

Inge Grundke-Iqbal, Anne B. Johnson, Robert D. Terry, Henryk M. Wisniewski, Dr Khalid Iqbal

Journal:

Annals of Neurology

Year:

1979

Language:

english

File:

PDF, 780 KB

english, 1979

11

Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of guam

Susarla K. Shankar, Dr. Richard Yanagihara, Ralph M. Garruto, Inge Grundke-Iqbal, Kenneth S. Kosik, D. Carleton Gajdusek

Journal:

Annals of Neurology

Year:

1989

Language:

english

File:

PDF, 1.01 MB

english, 1989

12

Instationäre Wirbelschichttrocknung körniger Güter im überhitzten Wasserdampf

Dr.-Ing. M. Haufe, Dr.-Ing. E. Grundke, Prof. Dr.-Ing. Habil. L. Mörl

Journal:

Chemie Ingenieur Technik

Year:

1997

Language:

german

File:

PDF, 136 KB

german, 1997

13

Cell surface immunoglobulin. VI. Dynamics on a human lymphoma line

Inge Grundke-Iqbal, J. W. Uhr

Journal:

European Journal of Immunology

Year:

1974

Language:

english

File:

PDF, 503 KB

english, 1974

14

Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: Negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation

George C. Ruben, Jian-zhi Wang, Khalid Iqbal, Inge Grundke-Iqbal

Journal:

Microscopy Research and Technique

Year:

2005

Language:

english

File:

PDF, 2.88 MB

english, 2005

15

Alzheimer's Disease Abnormally Phosphorylated τ Is Dephosphorylated by Protein Phosphatase-2B (Calcineurin)

Cheng-Xin Gong, Toolsee J. Singh, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 517 KB

english, 1994

16

Guanosine Triphosphate Binding to β-Subunit of Tubulin in Alzheimer's Disease Brain: Role of Microtubule-Associated Protein τ

Sabiha Khatoon, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 1.18 MB

english, 1995

17

Phosphorylation of τ Protein by Casein Kinase-1 Converts It to an Abnormal Alzheimer-Like State

Toolsee J. Singh, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 404 KB

english, 1995

18

Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

Cheng-Xin Gong, Sadia Shaikh, Jian-Zhi Wang, Tanweer Zaidi, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 778 KB

english, 1995

19

Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain

Toolsee J. Singh, Tanweer Zaidi, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Molecular and Cellular Biochemistry

Year:

1996

Language:

english

File:

PDF, 777 KB

english, 1996

20

Rabbit IgG cross-reacts with Alzheimer neurofibrillary tangles

Arkam Rehman, Yunn-Chyn Tung, Khalid Iqbal, Inge Grundke-Iqbal

Journal:

Acta Neuropathologica

Year:

1994

Language:

english

File:

PDF, 1.75 MB

english, 1994

21

Zur Frage des Vorkommens des D (Rh0)-Antigens in menschlichen D-negativen Erythrozyten

O. W. Thiele, Inge Grundke, B. Urbaschek

Journal:

Naturwissenschaften (The Science of Nature)

Year:

1967

Language:

german

File:

PDF, 150 KB

german, 1967

22

Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases

J. Singh, Inge Grundke-Iqbal, Brad McDonald, Khalid Iqbal

Journal:

Molecular and Cellular Biochemistry

Year:

1994

Language:

english

File:

PDF, 1.17 MB

english, 1994

23

Über einen im Rhesus-Blutgruppensystem wirksamen Phenolwasserextrakt aus menschlichen Erythrozyten

O. W. Thiele, Inge Grundke, B. Urbaschek

Journal:

Annals of Hematology

Year:

1967

Language:

german

File:

PDF, 208 KB

german, 1967

24

Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration

Jin-Jing Pei, Heiko Braak, Cheng-Xin Gong, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Richard F. Cowburn

Journal:

Acta Neuropathologica

Year:

2002

Language:

english

File:

PDF, 275 KB

english, 2002

25

The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease

Yoshitaka Tatebayashi, Moon H. Lee, Liang Li, Khalid Iqbal, Inge Grundke-Iqbal

Journal:

Acta Neuropathologica

Year:

2003

Language:

english

File:

PDF, 485 KB

english, 2003

26

Metabolic/signal transduction hypothesis of Alzheimer’s disease and other tauopathies

Khalid Iqbal, Inge Grundke-Iqbal

Journal:

Acta Neuropathologica

Year:

2005

Language:

english

File:

PDF, 268 KB

english, 2005

27

Mechanisms of tau-induced neurodegeneration

Khalid Iqbal, Fei Liu, Cheng-Xin Gong, Alejandra del C. Alonso, Inge Grundke-Iqbal

Journal:

Acta Neuropathologica

Year:

2009

Language:

english

File:

PDF, 478 KB

english, 2009

28

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice

Julie Blanchard, Lukas Wanka, Yunn-Chyn Tung, María del Carmen Cárdenas-Aguayo, Frank M. LaFerla, Khalid Iqbal, Inge Grundke-Iqbal

Journal:

Acta Neuropathologica

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

29

Opportunities and challenges in developing Alzheimer disease therapeutics

Khalid Iqbal, Inge Grundke-Iqbal

Journal:

Acta Neuropathologica

Year:

2011

Language:

english

File:

PDF, 1.75 MB

english, 2011

30

An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide

Silvia Bolognin, Julie Blanchard, Xiaochuan Wang, Gustavo Basurto-Islas, Yunn Chyn Tung, Erik Kohlbrenner, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Acta Neuropathologica

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

31

Phosphothreonine-212 of Alzheimer Abnormally Hyperphosphorylated Tau is a Preferred Substrate of Protein Phosphatase-1

Abdur Rahman, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Neurochemical Research

Year:

2005

Language:

english

File:

PDF, 375 KB

english, 2005

32

Regulation of Phosphorylation of tau by Protein Kinases in Rat Brain

Amitabha Sengupta, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Neurochemical Research

Year:

2006

Language:

english

File:

PDF, 266 KB

english, 2006

33

Significance and mechanism of alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

Khalid Iqbal, Alejandra del C. Alonso, Ezzat El-Akkad, Cheng-Xin Gong, Niloufar Haque, Sabiha Khatoon, Jin-Jing Pei, Ichiro Tsujio, Jian-Zhi Wang, Inge Grundke-Iqbal

Journal:

Journal of Molecular Neuroscience

Year:

2002

Language:

english

File:

PDF, 82 KB

english, 2002

34

Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain

Yu Huang, Hitoshi Tanimukai, Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong

Journal:

European Journal of Neuroscience

Year:

2004

Language:

english

File:

PDF, 490 KB

english, 2004

35

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

Fei Liu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong

Journal:

European Journal of Neuroscience

Year:

2005

Language:

english

File:

PDF, 309 KB

english, 2005

36

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

Jian-Zhi Wang, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

European Journal of Neuroscience

Year:

2007

Language:

english

File:

PDF, 1001 KB

english, 2007

37

Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

Fei Liu, Bin Li, E-Jan Tung, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong

Journal:

European Journal of Neuroscience

Year:

2007

Language:

english

File:

PDF, 723 KB

english, 2007

38

OLIGODENDROGLIA FROM HUMAN AUTOPSIED BRAIN: BULK ISOLATION AND SOME CHEMICAL PROPERTIES

Khalid Iqbal, Inge Grundke-Iqbal, Henryk M. Wisniewski

Journal:

Journal of Neurochemistry

Year:

1977

Language:

english

File:

PDF, 989 KB

english, 1977

39

Immunochemical Properties of Ubiquitin Conjugates in the Paired Helical Filaments of Alzheimer Disease

George Perry, Paul Mulvihill, Victor A. Fried, Harry T. Smith, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 730 KB

english, 1989

40

Brain Levels of Microtubule-Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno-Slot-Blot Assay for Nanograms of the Protein

Sabiha Khatoon, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Journal of Neurochemistry

Year:

1992

Language:

english

File:

PDF, 434 KB

english, 1992

41

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

Cheng-Xin Gong, Toolsee J. Singh, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 771 KB

english, 1993

42

Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5

Cheng-Xin Gong, Fei Liu, Guoxin Wu, Sandra Rossie, Jerzy Wegiel, Liang Li, Inge Grundke-Iqbal, Khalid Iqbal

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 360 KB

english, 2004

43

Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain

Zhihou Liang, Fei Liu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong

Journal:

Journal of Neurochemistry

Year:

2007

Language:

english

File:

PDF, 335 KB

english, 2007

44

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

Yang Yu, Xiaoqin Run, Zhihou Liang, Yi Li, Fei Liu, Ying Liu, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 1.15 MB

english, 2009

45

Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

Ying Liu, Fei Liu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

46

Novel therapeutic strategies for neurodegenerative disease

Hitoshi TANIMUKAI, Takashi KUDO, Toshihisa TANAKA, Inge GRUNDKE-IQBAL, Khalid IQBAL, Masatoshi TAKEDA

Journal:

Psychogeriatrics

Year:

2009

Language:

english

File:

PDF, 536 KB

english, 2009

47

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules

Alonso, Alejandra del C., Grundke-Iqbal, Inge, Iqbal, Khalid

Journal:

Nature Medicine

Year:

1996

File:

PDF, 634 KB

1996

48

Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease

Wang, Jian-Zhi, Grundke-Iqbal, Inge, Iqbal, Khalid

Journal:

Nature Medicine

Year:

1996

File:

PDF, 689 KB

1996

49

Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates

Toolsee J. Singh, Inge Grundke-Iqbal, Wu Qiongli Wu, Ved Chauhan, Michal Novak, Eva Kontzekova, Khalid Iqbal

Journal:

Molecular and Cellular Biochemistry

Year:

1997

Language:

english

File:

PDF, 209 KB

english, 1997

50

Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5

Amitabha Sengupta, Qiongli Wu, Inge Grundke-Iqbal, Khalid Iqbal, Toolsee J. Singh

Journal:

Molecular and Cellular Biochemistry

Year:

1997

Language:

english

File:

PDF, 53 KB

english, 1997

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